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Flowchart illustrating the concept of Metformin affecting AMPK to improve glucose metabolism, with a central circle labeled 'Metformin (Pharmacophore)', and three surrounding labeled arrows describing: 1) 'Ganglionic block of the LBG transmission from new intra-islet neurons may reduce pancreatic suppression by sympathetic nerves, thus stimulating insulin secretion', 2) 'Inhibition of hepatic gluconeogenesis primarily via the AMP-activated protein kinase (AMPK) pathway, reducing glucose production', and 3) 'Activation of AMPK in muscle enhances glucose uptake and fatty acid oxidation, lowering blood glucose'.

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